Protein Details: Calcium-activated chloride channel regulator 3A-1

Protein ID

ICDB_Pro_1605

Protein Name

Calcium-activated chloride channel regulator 3A-1

Gene Name

Clca3a1; Clca1

Organism

Mus musculus (Mouse)

Length

902 amino acids

AlphaFoldDB

AF-Q9QX15-F1-model_v4.pdb

Function

Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner.

Sequence

MVPGLQVLLFLTLHLLQNTESSMVHLNSNGYEGVVIAINPSVPEDERLIPSIKEMVTQASTYLFEASQGRVYFRNISILVPMTWKSKPEYLMPKRESYDKADVIVADPHLQHGDDPYTLQYGQCGDRGQYIHFTPNFLLTDNLRIYGPRGRVFVHEWAHLRWGVFDEYNVDQPFYMSRKNTIEATRCSTRITGTNVVHNCERGNCVTRACRRDSKTRLYEPKCTFIPDKIQTAGASIMFMQNLNSVVEFCTEKNHNAEAPNLQNKMCNRRSTWDVIKTSADFQNAPPMRGTEAPPPPTFSLLKSRRRVVCLVLDKSGSMDKEDRLIRMNQAAELYLTQIVEKESMVGLVTFDSAAHIQNYLIKITSSSDYQKITANLPQQASGGTSICHGLQAGFQAITSSDQSTSGSEIVLLTDGEDNGIRSCFEAVSRSGAIIHTIALGPSAARELETLSDMTGGLRFYANKDLNSLIDAFSRISSTSGSVSQQALQLESKAFDVRAGAWINGTVPLDSTVGNDTFFVITWMVKKPEIILQDPKGKKYTTSDFQDDKLNIRSARLQIPGTAETGTWTYSITGTKSQLITMTVTTRARSPTMEPLLATAHMSQSTAQYPSRMIVYARVSQGFLPVLGANVTALIEAEHGHQVTLELWDNGAGADTVKNDGIYTRYFTDYHGNGRYSLKVRVQAQRNKTRLSLRQKNKSLYIPGYVENGKIVLNPPRPDVQEEAIEATVEDFNRVTSGGSFTVSGAPPDGDHARVFPPSKVTDLEAEFIGDYIHLTWTAPGKVLDNGRAHRYIIRMSQHPLDLQEDFNNATLVNASSLIPKEAGSKETFKFKPETFKIANGIQLYIAIQADNEASLTSEVSNIAQAVKLTSLEDSISALGDDISAISMTIWGLTVIFNSILN

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 155; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 159; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 166; /ligand="Zn(2+)"; /ligand_note="catalytic";

Disease

Location

Highly expressed in skin and spleen; and at lower levels in kidney and liver (PubMed:9822685; PubMed:10072771). Also detected in lung and brain (PubMed:9822685). Not detected in lung or brain (PubMed:10072771). Not detected in lung or brain (PubMed:10072771). Not detected in lung or brain (PubMed:10072771). In lung; localizes to respiratory epithelia of the bronchi and trachea and the submucosal glands (PubMed:9822685)

DOI ID

10.1074/jbc.273.48.32096; 10.1016/s0378-1119(98)00620-9; 10.1126/science.1112014; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1016/j.cell.2010.12.001

RefSeq

NP_034029.2